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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9833464 B1

PDFFull Text
Date of Patent:
Dec. 05, 2017

Filed:

Dec. 29, 2010

Target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and manufacturing method thereof

Applicants:

IN San Kim, Daegu, KR;

Byung Heon Lee, Daegu, KR;

Maggie J M LU, Hsinchu, TW;

Hsiang-fa Liang, Hsinchu, TW;

Yi-ju Ko, Xinbei, TW;

Ya-chin Lo, Taichung, TW;

Li-wen Chang, Hsinchu, TW;

Ming-cheng Wei, Taoyuan, TW;

Inventors:

In San Kim, Daegu, KR;

Byung Heon Lee, Daegu, KR;

Maggie J M Lu, Hsinchu, TW;

Hsiang-Fa Liang, Hsinchu, TW;

Yi-ju Ko, Xinbei, TW;

Ya-Chin Lo, Taichung, TW;

Li-Wen Chang, Hsinchu, TW;

Ming-Cheng Wei, Taoyuan, TW;

Assignees:

KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Daegu, KR;

INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE, Hsinchu, TW;

Attorney:

Lucas & Mercanti, LLP

Primary Examiner:

Prema Mertz

Int. Cl.
CPC ...
A61K 31/70 (2006.01); A61K 31/704 (2006.01); A61K 47/48 (2006.01); A61K 9/127 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/704 (2013.01); A61K 9/1271 (2013.01); A61K 47/48815 (2013.01); A61K 38/00 (2013.01);
Abstract

The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.

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