The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2017
Filed:
Oct. 05, 2012
Applicant:
Aveo Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Sylvie Vincent, Somerville, MA (US);
Kristan Meetze, Lexington, MA (US);
Bin Feng, Newton, MA (US);
Steven Tyler, Boston, MA (US);
Steve Bottega, Cambridge, MA (US);
Richard Nicoletti, Southborough, MA (US);
Donna McIntosh, Chelmsford, MA (US);
Jeno Gyuris, Lincoln, MA (US);
Assignee:
AVEO Pharmaceuticals, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/395 (2006.01); C12Q 1/68 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6881 (2013.01); A61K 39/39558 (2013.01); G01N 33/574 (2013.01);
Abstract
A diagnostic method for predicting quantitatively whether a human tumor will be sensitive or resistant to treatment with an ERBB3 inhibitor, e.g, an anti-ERBB3 antibody, is disclosed. The method is based on measurement of NRG1 expression at the RNA level, or at the protein level, in a tissue sample from the tumor.