The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 28, 2017

Filed:

Apr. 08, 2014
Applicants:

University of Iowa Research Foundation, Iowa City, IA (US);

University of Kansas, Lawrence, KS (US);

Inventors:

Ziying Yan, Iowa City, IA (US);

John F. Engelhardt, Iowa City, IA (US);

Jianming Qiu, Overland Park, KS (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); A61K 39/23 (2006.01); C12N 15/00 (2006.01); C07K 1/00 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01); C12N 15/86 (2006.01); C12N 15/864 (2006.01); C07K 14/435 (2006.01);
U.S. Cl.
CPC ...
C12N 7/00 (2013.01); A61K 39/00 (2013.01); A61K 39/23 (2013.01); C12N 15/86 (2013.01); A61K 2039/5256 (2013.01); C07K 14/435 (2013.01); C12N 15/8645 (2013.01); C12N 2750/14111 (2013.01); C12N 2750/14121 (2013.01); C12N 2750/14132 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14144 (2013.01); C12N 2750/14145 (2013.01); C12N 2750/14322 (2013.01); C12N 2750/14333 (2013.01); C12N 2810/6027 (2013.01);
Abstract

The invention provides an isolated chimeric virus comprising bocavirus capsid protein, e.g., an isolated chimeric virus comprising human bocavirus capsid protein, and a recombinant adeno-associated viral (AAV) genome, an isolated recombinant bocavirus (rBoV) comprising human bocavirus capsid protein and a recombinant Boy genome, and uses therefor, for example, in gene therapy for diseases in a mammal including diseases with aberrant expression of an endogenous gene product.


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