The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2017
Filed:
Apr. 07, 2016
Applicant:
Olon S.p.a., Rodano, IT;
Inventors:
Assignee:
OLON S.P.A., Rodano, IT;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/00 (2006.01); C07D 487/04 (2006.01); C07C 69/76 (2006.01); C07C 69/78 (2006.01); C07C 51/41 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07C 51/412 (2013.01); C07C 69/76 (2013.01); C07C 69/78 (2013.01); C07B 2200/07 (2013.01); C07B 2200/13 (2013.01);
Abstract
Disclosed is a novel process for the synthesis of tofacitinib citrate on an industrial scale with high yields and purity starting with cis-(1-benzyl-4-methyl-piperidin-3-yl)methylamine bis-hydrochloride racemate (intermediate VIII), which comprises: