The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 28, 2017

Filed:

Feb. 23, 2012
Applicants:

Renata Pasqualini, Houston, TX (US);

Wadih Arap, Houston, TX (US);

Juri Gelovani, Missouri City, TX (US);

Frank C. Marini, Iii, Houston, TX (US);

Amin Hajitou, Houston, TX (US);

Mian Alauddin, Houston, TX (US);

Martin Trepel, Freiburg, DE;

Inventors:

Renata Pasqualini, Houston, TX (US);

Wadih Arap, Houston, TX (US);

Juri Gelovani, Missouri City, TX (US);

Frank C. Marini, III, Houston, TX (US);

Amin Hajitou, Houston, TX (US);

Mian Alauddin, Houston, TX (US);

Martin Trepel, Freiburg, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/23 (2006.01); C12N 15/00 (2006.01); C07H 21/04 (2006.01); A61K 47/48 (2006.01); A61K 48/00 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48238 (2013.01); A61K 47/48776 (2013.01); A61K 48/00 (2013.01); C12N 15/86 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14145 (2013.01); C12N 2795/14143 (2013.01); C12N 2810/405 (2013.01); C12N 2810/85 (2013.01);
Abstract

Embodiments of the invention are generally directed to compositions and methods of delivering one or more transgene to a target cell, such as a tumor cell, in a site-specific manner to achieve enhanced expression and to constructs and compositions useful in such applications. In certain aspects, expression from a therapeutic nucleic acid may be assessed prior to administration of a treatment or diagnostic procedure to or on a subject.


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