The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2017
Filed:
Oct. 12, 2010
Richard Malley, Beverly, MA (US);
Porter Anderson, Key Largo, FL (US);
Yingjie LU, West Roxbury, MA (US);
George A. Robertson, Fairfax Station, VA (US);
Mark Alderson, Bainbridge Island, WA (US);
Jean-francois Lucien Maisonneuve, Federal Way, WA (US);
Andrea Maria Tate, Issaquah, WA (US);
Waldely DE Oliveira Dias, Sao Paulo, BR;
Viviane Maimoni Gonçalves, Sao Paulo, BR;
Richard Malley, Beverly, MA (US);
Porter Anderson, Key Largo, FL (US);
Yingjie Lu, West Roxbury, MA (US);
George A. Robertson, Fairfax Station, VA (US);
Mark Alderson, Bainbridge Island, WA (US);
Jean-Francois Lucien Maisonneuve, Federal Way, WA (US);
Andrea Maria Tate, Issaquah, WA (US);
Waldely de Oliveira Dias, Sao Paulo, BR;
Viviane Maimoni Gonçalves, Sao Paulo, BR;
Children's Medical Center Corporation, Boston, MA (US);
Path Vaccine Solutions, Seattle, WA (US);
Fundacao Butantan, Sao Paulo, BR;
Abstract
The present invention provides for immunogenic compositions and methods for producing an immunogenic composition with multiple immunity-inducing fractions of killed, whole-cellby selectively disrupting a whole cell bacterial preparation in such a manner that a soluble fraction that induces a primarily antibody response, and a cellular fraction that induces a primarily antibody-independent response, remain in the immunogenic composition.