The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 28, 2017
Filed:
Oct. 26, 2012
Applicant:
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Inventors:
Stephen J. Blakemore, Littleton, MA (US);
Bin Li, Belmont, MA (US);
George J. Mulligan, Lexington, MA (US);
Matthew C. Schu, Somerville, MA (US);
Peter G. Smith, Arlington, MA (US);
Assignee:
Millennium Pharmaceuticals, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); G01N 33/574 (2006.01); C12Q 1/68 (2006.01); G06F 19/00 (2011.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57484 (2013.01); G06F 19/328 (2013.01); C12Q 2600/106 (2013.01); C12Q 2600/156 (2013.01); G01N 2800/52 (2013.01); G01N 2800/60 (2013.01);
Abstract
Disclosed herein are markers whose mutational status is associated with sensitivity to treatment with NAE inhibitors. Mutational status is determined by measurement of characteristics of markers associated with the marker genes. Compositions and methods are provided to assess markers of marker genes to predict response to NAE inhibition treatment.