The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 28, 2017

Filed:

Jul. 12, 2016
Applicants:

National Health Research Institutes, Zhunan Town, TW;

Regents of the University of Minnesota, Minneapolis, MN (US);

Inventors:

Shau-Hua Ueng, Zhunan, TW;

Shiu-Hwa Yeh, Zhunan, TW;

Horace Loh, Little Canada, MN (US);

Yu-Sheng Chao, New York, NY (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5377 (2006.01); A61K 31/422 (2006.01); A61K 31/428 (2006.01); A61K 31/485 (2006.01); A61K 31/427 (2006.01); A61K 31/4439 (2006.01); G01N 33/50 (2006.01); A61K 31/426 (2006.01); A61K 31/454 (2006.01); G01N 33/94 (2006.01);
U.S. Cl.
CPC ...
A61K 31/426 (2013.01); A61K 31/422 (2013.01); A61K 31/427 (2013.01); A61K 31/428 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/485 (2013.01); A61K 31/5377 (2013.01); G01N 33/9486 (2013.01); G01N 2500/04 (2013.01); G01N 2500/10 (2013.01);
Abstract

Disclosed is an in vitro screening method for identifying an antagonist-to-agonist allosteric modifier of a mu-opioid receptor and an in vivo method for confirming that a test compound is such a modifier of a mu-opioid receptor. Also disclosed is a method for treating an opioid receptor-associated condition using a compound of Formula (I) and a pharmaceutical composition containing the same.


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