The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 28, 2017

Filed:

Jun. 05, 2015
Applicant:

Chs Pharma, Inc., Miami, FL (US);

Inventors:

Jang-Yen Wu, Boca Raton, FL (US);

Howard Malcolm Prentice, Boca Raton, FL (US);

Assignee:

CHS Pharma, Inc., Miami, FL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 45/00 (2006.01); A61K 38/00 (2006.01); A01N 37/18 (2006.01); A61K 31/27 (2006.01); A61K 38/19 (2006.01); A61K 31/192 (2006.01);
U.S. Cl.
CPC ...
A61K 31/27 (2013.01); A61K 31/192 (2013.01); A61K 38/193 (2013.01);
Abstract

Granulocyte colony-stimulating factor (G-CSF; a stem cell enhancer and facilitator), DETC-MeSO (a glutamate receptor partial antagonist and anti-excitotoxicity agent), and sulindac (a potent anti-oxidant and anti-inflammatory agent) each can protect brain tissue exposed to a cerebral ischemia/reperfusion injury, and minimize the size of infarcts that develop as a result of the injury. When administered in combination, these agents are effective at protecting brain tissue and minimizing the size of an infarct resulting from the injury at much lower concentrations compared to using a single agent.


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