The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2017
Filed:
May. 21, 2012
Francisco Martin Molina, Sevilla, ES;
Karim Benabdellah El Khlanji, Sevilla, ES;
Marien Cobo Pulido, Sevilla, ES;
Miguel Garcia Toscano, Sevilla, ES;
Pilar Munoz Fernandez, Sevilla, ES;
Francisco Martin Molina, Sevilla, ES;
Karim Benabdellah El Khlanji, Sevilla, ES;
Marien Cobo Pulido, Sevilla, ES;
Miguel Garcia Toscano, Sevilla, ES;
Pilar Munoz Fernandez, Sevilla, ES;
FUNDACIÓN PÚBLICA ANDALUZA PROGRESO Y SALUD, Seville, ES;
INSTITUTO DE SALUD CARLOS III, Madrid, ES;
Abstract
The invention relates to expression systems useful for regulated expression of a gene of interest based on the constitutive expression of the original TetR repressor and the expression of the polynucleotide driven by a constitutive promoter operably linked to an operator sequence for a tetracycline operator sequence. The system can be provided as two different polynucleotides or as an all-in-one vector. The invention also relates to vectors, host cells and viral particles according to the invention as well as to the uses thereof for in vitro and in vivo production of products of interest or for therapy.