The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2017
Filed:
Jan. 22, 2015
Denise R. Cooper, St. Petersburg, FL (US);
Cesario Borlongan, Tampa, FL (US);
Paula Cole Bickford, Ruskin, FL (US);
Niketa A. Patel, Land O'Lakes, FL (US);
Lisa Gould, Warwick, RI (US);
Denise R. Cooper, St. Petersburg, FL (US);
Cesario Borlongan, Tampa, FL (US);
Paula Cole Bickford, Ruskin, FL (US);
Niketa A. Patel, Land O'Lakes, FL (US);
Lisa Gould, Warwick, RI (US);
University of South Florida, Tampa, FL (US);
The United States of America as Represented by the Department of Veterans Affairs, Washington, DC (US);
Abstract
A method of treating traumatic brain injury (TBI) and other neurological disorders is presented herein. Both conditioned media (CM) containing long non-coding RNAs such as NEAT1 (nuclear enriched abundant transcript 1) and MALAT1 (metastasis associated lung adenocarcinoma transcript 1) as well as human adipose-derived stem cells (hADSCs) themselves (Tx), when administered at least 3 hours post injury, were found to significantly ameliorate motor and cognitive functions in young, but not aged, mice undergoing TBI. Significant reduction in cortical damage and hippocampal cell loss was observed in both Tx and CM groups in young rats, whereas less neuroprotection was detected in the aged rats and mainly in the Tx group but not the CM group, which may in part result from decreased homing of the cells to the spleen.