The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 21, 2017

Filed:

Dec. 12, 2013
Applicants:

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Aravive Biologics, Inc., Houston, TX (US);

Inventors:

Amato J. Giaccia, Stanford, CA (US);

Erinn Bruno Rankin, Waltham, MA (US);

Jennifer R. Cochran, Stanford, CA (US);

Douglas Jones, Newton, MA (US);

Mihalis Kariolis, Stanford, CA (US);

Katherine Fuh, St. Louis, MO (US);

Yu Miao, Sunnyvale, CA (US);

Susan Hershenson, Palo Alto, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/12 (2006.01); C07K 16/46 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C12N 9/12 (2013.01); A61K 45/06 (2013.01); C07K 16/46 (2013.01); C07K 2319/30 (2013.01); C07K 2319/32 (2013.01); C12Y 207/10001 (2013.01);
Abstract

Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.


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