The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2017
Filed:
Jan. 30, 2015
Egis Gyogyszergyar Zrt., Budapest, HU;
Istvan Ling, Budapest, HU;
Gyorgy Jeges, Vilonya, HU;
Gyorgyi Kovanyine Lax, Budapest, HU;
Balazs Volk, Budapest, HU;
Peter Gregor, Szekesfehervar, HU;
Jeno Peter Seres, Budapest, HU;
Andras Dancso, Budapest, HU;
Zoltan Varga, Budapest, HU;
Eva Szabo, Budapest, HU;
EGIS GYOGYSZERGYAR ZRT., Budapest, HU;
Abstract
The invention relates to an improved process for the preparation of pharmaceutical active ingredients and also to high purity salts and pharmaceutical compositions prepared by said process. More particularly the invention relates to an economical process for the preparation of the compound having the international non-proprietary name (INN) vortioxetine and the chemical nomenclature 1-[2-(2,4-dimethyl-phenylsulfanyl)-phenyl]-piperazine. Vortioxetine corresponds to the following Formula Still more particularly the invention relates to the preparation of high purity vortioxetine L-(+)-mandelate salt of the Formula IX, the conversion of this salt into other highly pure salts and also to the formulation of said salts.