The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 21, 2017

Filed:

Apr. 21, 2014
Applicant:

University of Kentucky Research Foundation, Lexington, KY (US);

Inventors:

Joe Chappell, Lexington, KY (US);

Tom D. Niehaus, Lexington, KY (US);

Kristin Linscott, Lexington, KY (US);

Assignee:
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/16 (2006.01); C07K 14/00 (2006.01); A61K 38/45 (2006.01); C12N 9/10 (2006.01);
U.S. Cl.
CPC ...
A61K 38/45 (2013.01); C12N 9/1085 (2013.01); C12Y 205/01021 (2013.01);
Abstract

A compound is provided which comprises at least a portion of an amino acid linker-domain from squalene synthase. In alternative forms, the compound can include the amino-acid linker-domain from various fungus, includingor the compound can be the functional equivalent and/or mimics an amino acid linker-domain from squalene synthase. A pharmaceutical composition includes the compound and may further include a pharmaceutical carrier. A method is provided for treating or controlling cholesterol metabolism and ergosterol metabolism in non-fungal organisms. One method includes a therapeutic treatment in humans by administering a therapeutically effective amount of the compound or pharmaceutical composition, to a patient in need of treatment, therefrom.


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