The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2017
Filed:
Aug. 20, 2014
Applicants:
Vib Vzw, Ghent, BE;
Katholieke Universiteit Leuven, K.u.leuven R&d, Leuven, BE;
Universiteit Gent, Ghent, BE;
Inventors:
Jean-Christophe Marine, Brussels, BE;
Eleonora Leucci, Brussels, BE;
Joke Vandesompele, Zulte, BE;
Pieter Mestdagh, Bruges, BE;
Assignees:
VIB VZW, Ghent, BE;
KATHOLIEKE UNIVERSITEIT LEUVEN, K.U.LEUVEN R&D, Leuven, BE;
UNIVERSITEIT GENT, Ghent, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 31/713 (2006.01); C12N 15/113 (2010.01); A61K 31/7105 (2006.01); C12Q 1/68 (2006.01); G01N 33/574 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/713 (2013.01); A61K 31/7105 (2013.01); A61K 45/06 (2013.01); C12N 15/1135 (2013.01); C12Q 1/6886 (2013.01); G01N 33/5743 (2013.01); C12N 2310/113 (2013.01); C12N 2320/31 (2013.01); C12Q 2600/112 (2013.01); C12Q 2600/158 (2013.01);
Abstract
This disclosure relates to the field of cancer, particularly the field of melanoma. It was found that a particular long non-coding RNA (lncRNA) is specifically up-regulated in melanoma (but not other tumor) cells as compared to melanocytes. Inhibition of this lncRNA in melanoma cells leads to induction of apoptosis and is a novel therapeutic strategy in the treatment of melanoma.