The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 21, 2017

Filed:

May. 15, 2014
Applicant:

Topokine Therapeutics, Inc., Newton, MA (US);

Inventors:

Michael S. Singer, Newton Center, MA (US);

Murat V. Kalayoglu, Silver Spring, MD (US);

Assignee:

Topokine Therapeutics, Inc., Parsippany, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/5575 (2006.01); A61K 8/34 (2006.01); A61K 8/36 (2006.01); A61K 9/00 (2006.01); A61K 47/12 (2006.01); A61Q 19/06 (2006.01); A61K 47/10 (2017.01); A61K 8/37 (2006.01); A61K 8/69 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5575 (2013.01); A61K 8/34 (2013.01); A61K 8/345 (2013.01); A61K 8/361 (2013.01); A61K 8/37 (2013.01); A61K 8/69 (2013.01); A61K 9/0014 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61Q 19/06 (2013.01);
Abstract

Described herein are compositions comprising a prostaglandin FP receptor agonist (PFPRA) compound and a fatty acid, e.g., oleic acid, that, when topically applied to the skin, locally delivers a therapeutically effective amount of the PFPRA compound or active metabolite thereof to subcutaneous fat under the skin. The therapeutic effect is, for example, reduction of the subcutaneous fat under the skin. Further provided are methods of reducing body fat in a subject comprising topically administering the composition to the subject. The present invention also provides kits comprising the composition and instructions for use.


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