The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 21, 2017
Filed:
Sep. 10, 2015
The United States of America, As Respresented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
Michael R. Boyd, Mobile, AL (US);
Kirk R. Gustafson, Frederick, MD (US);
Charles L. Cantrell, Longmont, CO (US);
Abstract
The present invention provides a compound of the formula (I) or (II), wherein Ris H, alkyl, alkenyl or aryl, Ris H, alkyl or aryl, Ris H, a alkyl, alkenyl or aryl, Rand R-Rare independently R, C(O)Ror SOR, wherein Ris H, alkyl, alkenyl or aryl, and Ris R, C(O)Ror SOR, wherein Ris H, alkyl, alkenyl or aryl. Rcan be unsubstituted or substituted with one or more oxo(═O), OR, OC(O)R, OSOR, NHR, NHC(O)Rand NHSORgroups. Ris H, alkyl, alkenyl, or aryl. Rcan be unsubstituted or substituted with one or more groups such as oxo(═O), OR, COR, CORand OC(O)R. Ris H, or a unsubstituted or substituted alkyl, alkenyl or aryl. The present invention further provides a composition comprising at least one compound of the present invention and a pharmaceutically acceptable carrier, alone or in combination with at least one additional active agent. The present invention further provides a method of treating a condition treatable by the inhibition of vacuolar-type (H+)-ATPase and a method of treating cancer.