The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 14, 2017

Filed:

Apr. 17, 2013
Applicants:

Icahn School of Medicine AT Mount Sinai, New York, NY (US);

Westmead Institute for Medical Research, Westmead, AU;

Western Sydney Local Health District, Westmead, AU;

Inventors:

Barbara Murphy, Pelham Manor, NY (US);

Philip J. O'Connell, Sydney, AU;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/53 (2006.01); A61P 13/12 (2006.01); G01N 33/68 (2006.01); C07K 14/47 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5308 (2013.01); G01N 33/6893 (2013.01); C07K 14/47 (2013.01); G01N 2333/775 (2013.01); G01N 2800/085 (2013.01); G01N 2800/245 (2013.01); G01N 2800/50 (2013.01); G01N 2800/54 (2013.01);
Abstract

A method for identifying a kidney transplant recipient at an increased risk of developing interstitial fibrosis or tubular atrophy which comprises obtaining a post-transplant urine sample from the kidney transplant recipient; measuring the level of clusterin in the urine sample; comparing the level of clusterin in the patient sample to the level of clusterin in a control sample from the urine of a non-fibrotic kidney transplant recipient; diagnosing a kidney transplant recipient with a clusterin level that is significantly higher than the clusterin level in the control as being at an increased risk of developing interstitial fibrosis or tubular atrophy.


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