The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9816901 B1

PDF
Full Text
Expired
Date of Patent:
Nov. 14, 2017

Filed:

Dec. 13, 2013
Applicant:

Emd Millipore Corporation, Billerica, MA (US);

Inventor:

Benjamin Cacace, Tewksbury, MA (US);

Assignee:

EMD Millipore Corporation, Burlington, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 30/00 (2006.01); B01L 3/00 (2006.01); G01N 1/34 (2006.01); G01N 1/40 (2006.01); C07K 1/14 (2006.01); C07K 1/36 (2006.01); B01J 39/26 (2006.01); B01J 41/20 (2006.01); B01J 47/022 (2017.01); B01J 47/014 (2017.01); B01J 47/127 (2017.01);
U.S. Cl.
CPC ...
G01N 1/34 (2013.01); B01J 39/26 (2013.01); B01J 41/20 (2013.01); B01J 47/014 (2017.01); B01J 47/022 (2013.01); B01J 47/127 (2017.01); B01L 3/505 (2013.01); C07K 1/14 (2013.01); C07K 1/36 (2013.01); G01N 1/405 (2013.01); B01L 2200/12 (2013.01); B01L 2300/0681 (2013.01); B01L 2300/123 (2013.01);
Abstract

The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.


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