The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2017
Filed:
Nov. 01, 2013
Applicant:
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Inventors:
Elena Aikawa, Chestnut Hill, MA (US);
Masanori Aikawa, Chestnut Hill, MA (US);
Sophie New, Beckenham, GB;
Kevin Croce, West Roxbury, MA (US);
Assignee:
THE BRIGHAM AND WOMEN'S HOSPITAL, INC., Boston, MA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/113 (2010.01); A61K 31/713 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/713 (2013.01); A61K 38/00 (2013.01); C12N 2310/14 (2013.01); C12N 2320/30 (2013.01);
Abstract
The invention relates to methods for decreasing, inhibiting, preventing, or reducing matrix vesicle induced calcification by inhibiting the amount or formation of a complex comprising phosphatidylserine (PS), annexin II, annexin V or VI, and S100A9 or S100A12 in a macrophage.