The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2017
Filed:
Dec. 06, 2012
Applicant:
Atyr Pharma, Inc., San Diego, CA (US);
Inventors:
Ying Ji Buechler, Carlsbad, CA (US);
Chi-Fang Wu, San Diego, CA (US);
Ryan Andrew Adams, San Diego, CA (US);
Kristi Helen Piehl, San Diego, CA (US);
Jeffrey Greve, Berkeley, CA (US);
John D. Mendlein, Encinitas, CA (US);
Assignee:
aTyr Pharma, Inc., San Diego, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/96 (2006.01); A61K 38/43 (2006.01); C12N 9/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/93 (2013.01); A61K 38/00 (2013.01); C07K 2319/40 (2013.01);
Abstract
The present invention provides aspartyl-tRNA synthetase derived proteins (DRS polypeptides) with altered cysteine content, compositions comprising the same, and methods of using such polypeptides and compositions for treating or diagnosing a variety of conditions. The DRS polypeptides of the invention have immunomodulatory properties, and exhibit improved activity and stability.