The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2017
Filed:
Dec. 31, 2014
Shenzhen Salubris Pharmaceuticals Co., Ltd, Shenzhen, CN;
Tianjin University, Tianjin, CN;
Junbo Gong, Tianjin, CN;
Qi Wang, Tianjin, CN;
Qiuxiang Yin, Tianjin, CN;
Jingkang Wang, Tianjin, CN;
Xiaopeng Song, Tianjin, CN;
Baohong Hou, Tianjin, CN;
Liting Liao, Shenzhen, CN;
Duanming Tan, Shenzhen, CN;
Ziyuan Di, Shenzhen, CN;
TIANJIN UNIVERSITY, Tianjin, CN;
SHENZHEN SALUBRIS PHARMACEUTICALS CO., LTD, Shenzhen, CN;
Abstract
This invention provides a new preparation method of Clopidogrel Hydrogen Sulfate spherical crystal form I, using single 2-butanol as solvent, controlling the concentration, addition way and addition speed of sulfuric acid used to salify to shorten the process time, thus separating out Clopidogrel Hydrogen Sulfate from solution system stably with spherality. And the Clopidogrel Hydrogen Sulfate obtained complies with the requirements of the follow-up process on residual solvent, bulk density and mobility.