The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 14, 2017

Filed:

Jul. 22, 2015
Applicant:

Astrazeneca Ab, Sodertalje, SE;

Inventors:

Jorgen Blixt, Sodertalje, SE;

Michael David Golden, Macclesfield, GB;

Philip John Hogan, Macclesfield, GB;

David Michael Glanville Martin, Macclesfield, GB;

Francis Joseph Montgomery, Macclesfield, GB;

Zakariya Patel, Loughborough, GB;

John David Pittam, Macclesfield, GB;

George Joseph Sependa, Macclesfield, GB;

Christopher John Squire, Macclesfield, GB;

Nicholas Cartwright Alexander Wright, Macclesfield, GB;

Assignee:

Genzyme Corporation, Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 211/16 (2006.01); C07D 239/94 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); C07D 211/16 (2013.01); C07D 239/94 (2013.01);
Abstract

The present invention relates to chemical processes for the manufacture of certain quinazoline derivatives, or pharmaceutically acceptable salts thereof. The invention also relates to processes for the manufacture of certain intermediates useful in the manufacture of the quinazoline derivatives and to processes for the manufacture of the quinazoline derivatives utilizing said intermediates. In particular, the present invention relates to chemical processes and intermediates useful in the manufacture of the compound 4-(4-bromo-2-fluoroanilino)-6-methoxy-7-(1-methylpiperidin-4-ylmethoxy)quinazoline.


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