The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 14, 2017
Filed:
Sep. 19, 2014
Applicant:
Saint Louis University, St. Louis, MO (US);
Inventors:
Francis M. Sverdrup, Lake Saint Louis, MO (US);
Stephen J. Tapscott, Seattle, WA (US);
Assignee:
Saint Louis University, St. Louis, MO (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/00 (2006.01); A61K 31/397 (2006.01); A61K 31/551 (2006.01); A61K 31/517 (2006.01); A61K 31/4745 (2006.01);
U.S. Cl.
CPC ...
A61K 31/551 (2013.01); A61K 31/4745 (2013.01); A61K 31/517 (2013.01);
Abstract
The use of BETi as a potential treatment for FSHD is provided. Specifically, the use of BETi, and particularly selective BETi for BRD4, are shown to inhibit DUX4 expression which is expected to result in a decrease in the severity of symptoms of FSHD. Further, the treatments are shown to work when pulsed as opposed to continuous. This allows for a BETi to be supplied to a human in a pulse, and then allows the human to not need any additional treatment for a window at least as long as the one of the treatment pulse.