The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 14, 2017

Filed:

Jun. 03, 2016
Applicant:

The University of Rochester, Rochester, NY (US);

Inventors:

Harris A. Gelbard, Pittsford, NY (US);

Stephen Dewhurst, Rochester, NY (US);

Val S. Goodfellow, Encinitas, CA (US);

Colin J. Loweth, San Marcos, CA (US);

Torsten Wiemann, Encinitas, CA (US);

Assignee:

The University of Rochester, Rochester, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01); A61K 31/437 (2006.01); A61K 45/06 (2006.01); C07D 487/04 (2006.01); A61K 31/438 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); A61K 31/553 (2006.01); C07D 471/10 (2006.01); A61K 31/444 (2006.01);
U.S. Cl.
CPC ...
A61K 31/437 (2013.01); A61K 31/438 (2013.01); A61K 31/444 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 31/553 (2013.01); A61K 45/06 (2013.01); C07D 471/04 (2013.01); C07D 471/10 (2013.01); C07D 487/04 (2013.01);
Abstract

Provided are compounds having an inhibitory effect on Mixed Lineage Kinases. The compounds include substituted pyrrolo[2,3-b]pyridines having Formula IX Also provided are pharmaceutical compositions, methods of preparing the compounds, synthetic intermediates, and methods of using the compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions which are affected by Mixed Lineage Kinase inhibition. Also provided are methods of treatment neuropsychiatric disorders which comprise the inhibition of Mixed Lineage Kinases.


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