The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2017
Filed:
Oct. 05, 2011
Steven C. George, Irvine, CA (US);
Christopher C. W. Hughes, Irvine, CA (US);
Abraham P. Lee, Irvine, CA (US);
Monica Moya, Irvine, CA (US);
Yu-hsiang Hsu, Pasadena, CA (US);
Steven C. George, Irvine, CA (US);
Christopher C. W. Hughes, Irvine, CA (US);
Abraham P. Lee, Irvine, CA (US);
Monica Moya, Irvine, CA (US);
Yu-Hsiang Hsu, Pasadena, CA (US);
The Regents of the University of California, Oakland, CA (US);
Abstract
Provided is a process for creating a 3D metabolically active microtissue perfused with living microvessels which have a direct fluidic connection with neighboring microfluidic channels. The process comprises preparing a template comprising a plurality of channels, and creating a network within said channels, said network comprising microfluidic channels, metabolically active living microvessels, and microtissues. The microvessels can sprout from said microvessels and/or form within the microtissue in response to a stimulus applied from said microfluidic channels or stimulus derived from the said tissues. In another embodiment, a device is provided comprising a supportive structure, one or more microfluidic channels, one or more microtissue compartments, and one or more microvessels, whereby the microvessels connect said microfludic channels and microtissue and perfuse the microtissue to deliver fluid from the microfluidic channels to the microtissues.