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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9809821 B1

PDFFull Text
Expired
Date of Patent:
Nov. 07, 2017

Filed:

Dec. 01, 2015

Compositions and methods for efficacious and safe delivery of sirna using specific chitosan-based nanocomplexes

Applicant:

Polyvalor, Limited Partnership, Montreal, CA;

Inventors:

Abderrazzak Merzouki, Laval, CA;

Michael D. Buschmann, Montreal, CA;

Assignee:

POLYVALOR, LIMITED PARTNERSHIP, Montreal, CA;

Attorneys:

Nixon Peabody LLP

Elizabeth W. Baio

Nicole D. Kling

Primary Examiner:

Kimberly Chong

Int. Cl.
CPC ...
A61K 48/00 (2006.01); C12N 15/113 (2010.01); A61K 38/00 (2006.01); A61K 38/28 (2006.01); A61K 45/06 (2006.01); A61K 9/51 (2006.01); A61K 31/40 (2006.01); A61K 31/403 (2006.01); A61K 31/4985 (2006.01); A61K 31/64 (2006.01); C12N 15/87 (2006.01); C12N 15/11 (2006.01); A61K 31/713 (2006.01); A61K 47/36 (2006.01);
U.S. Cl.
CPC ...
C12N 15/1138 (2013.01); A61K 9/5161 (2013.01); A61K 31/40 (2013.01); A61K 31/403 (2013.01); A61K 31/4985 (2013.01); A61K 31/64 (2013.01); A61K 31/713 (2013.01); A61K 38/005 (2013.01); A61K 38/28 (2013.01); A61K 45/06 (2013.01); A61K 47/36 (2013.01); C12N 15/111 (2013.01); C12N 15/113 (2013.01); C12N 15/1137 (2013.01); C12N 15/87 (2013.01); C12N 2310/14 (2013.01); C12N 2310/531 (2013.01); C12N 2320/31 (2013.01); C12N 2320/32 (2013.01);
Abstract

There is disclosed a composition and a method for the efficient delivery of a therapeutic RNAi-inducing nucleic acid to cells both in vitro and in vivo through specific formulations of a non viral delivery system using chitosans. Particularly, the composition contains a nucleic acid and a specific chitosan that has the following physico-chemical properties: a number-average molecular weight between 5 kDa and 200 kDa, a degree of deacetylation between 80% and 95% and a chitosan amine to nucleic acid phosphate ratio below 20.

Find Patent Forward Citations

Merzouki, Abderrazzak. (2017). Compositions and methods for efficacious and safe delivery of sirna using specific chitosan-based nanocomplexes (U.S. Patent No. 9809821). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/9809821

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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