The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2017
Filed:
Oct. 22, 2014
Applicant:
University of Washington Through Its Center for Commercialization, Seattle, WA (US);
Inventors:
Xiaohu Gao, Seattle, WA (US);
Hong Yan Liu, Seattle, WA (US);
Assignee:
University of Washington Through its Center for Commercialization, Seattle, WA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07K 14/47 (2006.01); A61K 38/17 (2006.01); A61K 31/713 (2006.01); C12N 15/11 (2006.01); C12N 15/87 (2006.01);
U.S. Cl.
CPC ...
C07K 14/47 (2013.01); A61K 31/713 (2013.01); A61K 38/1709 (2013.01); C07K 14/4703 (2013.01); C12N 15/111 (2013.01); C12N 15/87 (2013.01); C07K 2319/21 (2013.01); C07K 2319/80 (2013.01); C07K 2319/85 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12N 2310/3519 (2013.01); C12N 2320/32 (2013.01);
Abstract
Disclosed herein are chimeric proteins that include one or more double stranded nucleic acid binding domains (dsNABD) and one or more polyHis domains, and compositions that further include a therapeutic double stranded nucleic acid and a targeting ligand bound to the therapeutic double stranded nucleic acid, wherein the dsNABD of the chimeric protein is bound to the therapeutic double stranded nucleic acid, and uses of the compositions to treat disease.