The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 07, 2017

Filed:

Nov. 12, 2012
Applicant:

Re:viral Ltd, London, GB;

Inventors:

Stuart Cockerill, London, GB;

Christopher Pilkington, London, GB;

James Lumley, London, GB;

Richard Angell, London, GB;

Neil Mathews, London, GB;

Assignee:

ReViral Limited, Stevenage, GB;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 403/06 (2006.01); A61K 31/4184 (2006.01); A61K 31/437 (2006.01); A61K 31/4747 (2006.01); A61K 31/5386 (2006.01); C07D 401/06 (2006.01); C07D 413/06 (2006.01); C07D 471/10 (2006.01); A61K 31/5513 (2006.01); A61K 45/06 (2006.01); C07D 498/10 (2006.01);
U.S. Cl.
CPC ...
C07D 403/06 (2013.01); A61K 31/4184 (2013.01); A61K 31/437 (2013.01); A61K 31/4747 (2013.01); A61K 31/5386 (2013.01); A61K 31/5513 (2013.01); A61K 45/06 (2013.01); C07D 401/06 (2013.01); C07D 413/06 (2013.01); C07D 471/10 (2013.01); C07D 498/10 (2013.01);
Abstract

Benzimidazoles of formula (I): wherein: A is 5- to 12-membered aryl or 5- to 12-membered heteroaryl, each of which is unsubstituted or substituted; Y is a single bond, —(CH)—, —X—, —CH—X—, or —X—CH—; X is —O—, —S—, —N(R)—, >C═O, >S(═O), >S(═O), —O—C(═O)—, —C(═O)—O—, N(R)—C(═O)—, or —C(═O)—N(R)—; each L is independently a single bond, Calkylene, Calkenylene or Calkynylene; Ris Calkyl, Calkenyl or Calkynyl, each of which is unsubstituted or substituted; each Z is independently —N(R), —OR, —SR, —S(═O)R, —S(═O)R; each Ris independently hydrogen, Calkyl, Calkenyl or Calkynyl, wherein said alkyl, alkenyl and alkynyl groups are unsubstituted or substituted; m is 0, 1, 2, or 3; n is 1, 2, or 3; and p is 1, 2, or 3; and the pharmaceutically acceptable salt thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.


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