The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 07, 2017

Filed:

Jul. 15, 2010
Applicants:

Roger Tsien, La Jolla, CA (US);

Emilia Olson, Seattle, WA (US);

Tao Jiang, San Diego, CA (US);

Quyen Nguyen, Del Mar, CA (US);

Michael Whitney, San Diego, CA (US);

Inventors:

Roger Tsien, La Jolla, CA (US);

Emilia Olson, Seattle, WA (US);

Tao Jiang, San Diego, CA (US);

Quyen Nguyen, Del Mar, CA (US);

Michael Whitney, San Diego, CA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61B 10/00 (2006.01); A61B 5/00 (2006.01); A61B 8/00 (2006.01); A61K 47/48 (2006.01); A61K 49/00 (2006.01); C07K 7/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/48215 (2013.01); A61K 47/48207 (2013.01); A61K 47/48238 (2013.01); A61K 47/48815 (2013.01); A61K 49/0032 (2013.01); A61K 49/0056 (2013.01); C07K 7/06 (2013.01);
Abstract

Disclosed herein, in certain embodiments, is a selective transport molecule with increased in vivo circulation. In some embodiments, a selective transport molecule disclosed herein has the formula (A-X-B-C)n-M, wherein C is a cargo moiety; A is a peptide with a sequence comprising 5 to 9 consecutive acidic amino acids, wherein the amino acids are selected from: aspartates and glutatmates; B is a peptide with a sequence comprising 5 to 20 consecutive basic amino acids; X is a linker; and M is a macromolecular carrier.


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