The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 31, 2017

Filed:

Oct. 25, 2013
Applicant:

Adisseo France S.a.s., Antony, FR;

Inventors:

Muriel Merkamm, Les Ulis, FR;

Dominique Louis, Forges les Bains, FR;

Karine Jaillardon, Saint Michel sur Orge, FR;

Dominique Thomas, Gif sur Yvette, FR;

Philippe Marliere, Mouscron, BE;

Assignee:

ADISSEO FRANCE S.A.S., Antony, FR;

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 13/12 (2006.01); C12P 19/40 (2006.01); C12P 21/02 (2006.01); C12P 11/00 (2006.01); C12P 13/02 (2006.01); C12N 9/10 (2006.01);
U.S. Cl.
CPC ...
C12P 13/12 (2013.01); C12N 9/1085 (2013.01); C12P 11/00 (2013.01); C12P 13/02 (2013.01); C12P 19/40 (2013.01); C12P 21/02 (2013.01); C12Y 205/01048 (2013.01);
Abstract

Provided is a method for producing L-methionine in which O-phospho-L-homoserine and methanethiol are enzymatically converted into L-methionine and H3PO4. Such a conversion is achieved by an enzyme called O-phospho-L-homoserine (OHPS) dependent methionine synthase. Also described are O-phospho-L-homoserine (OHPS) dependent methionine synthases, i.e. proteins which are able to enzymatically convert O-phospho-L-homoserine and methanethiol into L-methionine and H3PO4 as well as microorganisms which have been genetically modified so as to be able to produce L-methionine from O-phospho-L-homoserine and methanethiol. Furthermore described are methods to screen for enzymes that catalyze the conversion of O-phospho-L-homoserine and methanethiol into L-methionine and HPO.


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