The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2017
Filed:
Feb. 21, 2013
Applicants:
Brainstem Biotec Ltd., Tel-Aviv, IL;
Henry Ford Health System, Detroit, MI (US);
Inventors:
Chaya Brodie, Southfield, MI (US);
Shimon Slavin, Tel-Aviv, IL;
Assignees:
EXOSTEM BIOTEC LTD., Tel Aviv, IL;
HENRY FORD HEALTH SYSTEM, Detroit, MI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); A61K 35/12 (2015.01); C12N 5/0797 (2010.01); C12N 5/0793 (2010.01); A61K 35/28 (2015.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0623 (2013.01); A61K 35/28 (2013.01); C12N 5/0619 (2013.01); C12Q 1/6876 (2013.01); C12N 15/113 (2013.01); C12N 2310/141 (2013.01); C12N 2320/11 (2013.01); C12N 2330/10 (2013.01); C12N 2501/11 (2013.01); C12N 2501/115 (2013.01); C12N 2501/13 (2013.01); C12N 2501/385 (2013.01); C12N 2501/41 (2013.01); C12N 2501/65 (2013.01); C12N 2501/91 (2013.01); C12N 2501/998 (2013.01); C12N 2501/999 (2013.01); C12N 2506/025 (2013.01); C12N 2506/08 (2013.01); C12N 2506/1353 (2013.01); C12N 2506/1369 (2013.01); C12N 2506/1384 (2013.01); C12N 2506/1392 (2013.01); C12N 2510/00 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01);
Abstract
A method of generating neural stem cells or motor neurons is disclosed, the method comprising up-regulating a level of at least one exogenous miRNA and/or down-regulating at least one miRNA using an agent which hybridizes to the miRNA in mesenchymal stem cells (MSCs) or down-regulating Related to testis-specific, vespid and pathogenesis protein 1 (RTVP-1).