The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2017
Filed:
Dec. 05, 2013
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventor:
Sherie L. Morrison, Los Angeles, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 38/21 (2006.01); A61K 39/395 (2006.01); A61K 39/00 (2006.01); C07K 14/56 (2006.01); C07K 16/30 (2006.01); C07K 16/32 (2006.01); C07K 16/46 (2006.01); C07K 19/00 (2006.01); C07K 16/28 (2006.01); C07K 14/555 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); C07K 14/565 (2006.01); C07K 14/57 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/2896 (2013.01); A61K 38/212 (2013.01); A61K 38/215 (2013.01); A61K 38/217 (2013.01); A61K 39/39558 (2013.01); A61K 45/06 (2013.01); C07K 14/56 (2013.01); C07K 14/565 (2013.01); C07K 14/57 (2013.01); C07K 16/30 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); C07K 2317/56 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2319/00 (2013.01); C07K 2319/74 (2013.01);
Abstract
In various embodiments chimeric moieties (constructs) are provided that show significant efficacy against cancers. In certain embodiments the constructs comprise a targeting moiety that specifically binds CD138 attached to an interferon or to a mutant interferon. In certain embodiments, the constructs comprise anti-CD138 antibody attached to an interferon alpha (IFN-α) or to a mutant interferon alpha.