The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2017
Filed:
Sep. 30, 2014
Afasci, Inc., Redwood City, CA (US);
Kansas State University Research Foundation, Manhattan, KS (US);
The Regents of the University of California, Oakland, CA (US);
Duy H Hua, Manhattan, KS (US);
Lee-way Jin, Davis, CA (US);
Izumi Maezawa, Sacramento, CA (US);
Xinmin Xie, Burlingame, CA (US);
KANSAS STATE UNIVERSITY RESEARCH FOUNDATION, Manhattan, KS (US);
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, A CALIFORNIA CORPORATION, Oakland, CA (US);
AFASCI, INC., Redwood City, CA (US);
Abstract
Tricyclic pyrone compounds having high oral bioavailability, excellent blood-brain barrier permeability, and low toxicity are presented. Administration of the compounds to Alzheimer's Disease transgenic models resulted in substantially reduced soluble and insoluble Aβ species in the brain without affecting general behavior and motor coordination. Furthermore, in addition to blocking the toxicity and formation of both intraneuronal and extracellular Aβ aggregates, the compounds also increase cellular cholesterol efflux, restore axonal trafficking, and enhance hippocampal synaptic plasticity.