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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9802941 B1

PDFFull Text
Date of Patent:
Oct. 31, 2017

Filed:

Aug. 26, 2015

Compounds and methods for inhibiting histone demethylases

Applicant:

Gilead Sciences, Inc., Foster City, CA (US);

Inventors:

Thomas Boesen, Københan Ø, DK;

Marc Labelle, Basking Ridge, NJ (US);

Ying Yang, Fremont, CA (US);

Neerja Saraswat, Winnipeg, CA;

Dastagiri Dudekula, Winnipeg, CA;

Cyril John Cook, Winnipeg, CA;

Ramkrishna Reddy Vakiti, Winnipeg, CA;

Rui Zhang, Winnipeg, CA;

Farman Ullah, Winnipeg, CA;

Assignee:

GILEAD SCIENCES, INC., Foster City, CA (US);

Attorney:
Primary Examiner:

Brian J Davis

Int. Cl.
CPC ...
C07D 487/04 (2006.01); A61K 31/5355 (2006.01); C07D 413/12 (2006.01); C07D 409/14 (2006.01); A61K 31/506 (2006.01); C07D 213/79 (2006.01); C07D 413/14 (2006.01); C07D 401/14 (2006.01); A61K 31/501 (2006.01); A61K 31/4985 (2006.01); A61K 31/444 (2006.01); A61K 31/4439 (2006.01); A61K 31/4412 (2006.01); C07D 213/38 (2006.01); C07D 213/48 (2006.01); C07D 213/56 (2006.01); C07D 401/04 (2006.01); C07D 413/04 (2006.01); C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/444 (2013.01); A61K 31/4412 (2013.01); A61K 31/4439 (2013.01); A61K 31/4985 (2013.01); A61K 31/501 (2013.01); A61K 31/506 (2013.01); A61K 31/5355 (2013.01); C07D 213/38 (2013.01); C07D 213/48 (2013.01); C07D 213/56 (2013.01); C07D 213/79 (2013.01); C07D 401/04 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01);
Abstract

The present application relates to compounds being of Formula (I), (II), (III), (IV), (V), (VI), (IIIa), (IIIb), (IIIc), (IIId), (IIIe), (IIIf), and (IIIg). Compounds of Formula (I) have the structure: wherein Q, R, R, R, M, A and Y are as defined herein. The compounds of the application can modulate the activity of histone demethylases (HDMEs), and can be useful for the prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, e.g., cancer.

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