The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 31, 2017

Filed:

Oct. 09, 2007
Applicants:

Colin M. Tice, Elkins Park, PA (US);

Enrique L. Michelotti, Fort Washington, PA (US);

Robert E. Hormann, Melrose Park, PA (US);

Inventors:

Colin M. Tice, Elkins Park, PA (US);

Enrique L. Michelotti, Fort Washington, PA (US);

Robert E. Hormann, Melrose Park, PA (US);

Assignee:

Intrexon Corporation, Blacksburg, VA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); C07C 233/31 (2006.01); C07C 233/76 (2006.01); C07C 235/46 (2006.01); C07C 235/48 (2006.01); C07C 235/50 (2006.01); C07C 235/54 (2006.01); C07C 237/32 (2006.01); C07C 271/20 (2006.01); C07C 275/24 (2006.01); C07C 311/20 (2006.01); C07D 207/14 (2006.01); C07D 211/56 (2006.01); C07D 211/58 (2006.01); C07D 309/14 (2006.01); C07D 317/54 (2006.01); C07D 319/18 (2006.01); C07D 321/08 (2006.01); C07D 335/02 (2006.01); C07F 9/36 (2006.01); C07K 14/705 (2006.01); C07K 14/72 (2006.01); C12Q 1/68 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); C07C 233/31 (2013.01); C07C 233/76 (2013.01); C07C 235/46 (2013.01); C07C 235/48 (2013.01); C07C 235/50 (2013.01); C07C 235/54 (2013.01); C07C 237/32 (2013.01); C07C 271/20 (2013.01); C07C 275/24 (2013.01); C07C 311/20 (2013.01); C07D 207/14 (2013.01); C07D 211/56 (2013.01); C07D 211/58 (2013.01); C07D 309/14 (2013.01); C07D 317/54 (2013.01); C07D 319/18 (2013.01); C07D 321/08 (2013.01); C07D 335/02 (2013.01); C07F 9/36 (2013.01); C07K 14/70567 (2013.01); C07K 14/721 (2013.01); C12Q 1/6897 (2013.01); C07C 2601/02 (2017.05); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05);
Abstract

This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of ketones.


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