The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2017
Filed:
Jan. 11, 2017
Applicant:
Tongli Biomedical Co., Ltd., Zhangjigang, Jiangsu, CN;
Inventor:
Mingxin Qian, Jiangsu, CN;
Assignee:
TONGLI BIOMEDICAL CO., LTD., Zhangjigang, CN;
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/14 (2006.01); C07D 471/04 (2006.01); C07D 217/26 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01); C07D 217/26 (2013.01); C07B 2200/13 (2013.01);
Abstract
The present disclosure relates to a process and new intermediates for the synthesis of (R)-praziquantel, which is obtained through four steps in proper order, that is, condensation reaction, reduction reaction, acylation reaction and ring-closing reaction, using (1R)-2-substituted-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid as starting material. Overall, the present disclosure provides a (R)-praziquantel product with higher optical purity through a process route that is more cost effective and environmentally friendly.