The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2017
Filed:
Dec. 26, 2013
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Washington, DC (US);
University of Delaware, Newark, DE (US);
David J. Maloney, Point of Rocks, MD (US);
Andrew S. Rosenthal, Derwood, MD (US);
Ajit Jadhav, Chantilly, VA (US);
Thomas S. Dexheimer, Frederick, MD (US);
Anton Simeonov, Bethesda, MD (US);
Zhihao Zhuang, Wilmington, DE (US);
Qin Liang, Elkton, MD (US);
Diane K. Luci, Germantown, MD (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Washington, DC (US);
University of Delaware, Newark, DE (US);
Abstract
Disclosed are inhibitors of the USP1/UAF1 deubiquitinase complex, for example. of formula (I), wherein R, R, and Q are as defined herein, which are useful in treating diseases such as cancer, and improving the efficacy of DNA damaging agents in cancer treatment. Also disclosed is a composition comprising a pharmaceutically suitable carrier and at least one compound of the invention, a method of method of inhibiting a heterodimeric deubiquitinase complex in a cell, and a method of enhancing the chemotherapeutic treatment of cancer in a mammal undergoing treatment with an anti cancer agent. Further disclosed is a method of preparing compounds of the invention.