The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2017
Filed:
Apr. 21, 2014
Research Cooperation Foundation of Yeungnam University, Gyeongsangbuk-do, KR;
Byeong Seon Jeong, Daegu, KR;
Jung Ae Kim, Daegu, KR;
Tae gyu Nam, Gyeonggi-do, KR;
Hyun Ji Lee, Daegu, KR;
Dong Guk Kim, Daegu, KR;
You Ra Kang, Daegu, KR;
Jae Hui Been, Daegu, KR;
You Jin Jin, Daegu, KR;
Sushil Chandra Regmi, Gyeongsangbuk-do, KR;
Jaya Gautam, Gyeongsangbuk-do, KR;
Research Cooperation Foundation of Yeungnam University, Gyeongsangbuk-do, KR;
Abstract
An amidopyridinol derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including the amidopyridinol derivative as an active component represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof have an antiangiogenic effect in a chorioallantoic membrane model, and thus are useful as an agent for preventing or treating diseases associated with angiogenesis, and also have a colitis-inhibitory effect in a model of inflammatory bowel diseases, and thus are useful as an agent for preventing or treating inflammatory bowel diseases. Upon inoculation of lung cancer cells in a chorioallantoic membrane model, the amidopyridinol derivative of Chemical Formula 1 or the pharmaceutically acceptable salt thereof inhibits angiogenesis and tumor growth that are caused by tumorigenesis, and also inhibits the activity of cathepsin S that plays an important role in metastasis and invasion of cancer, and thus is useful as an inhibitor of cancer growth and metastasis.