The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2017
Filed:
Jun. 15, 2015
Applicants:
David Hook, Rheinfelden, CH;
Bernhard Riss, Huningue, FR;
Jianguang Zhou, Suzhou, CN;
Yunzhong LI, Juangsu, CN;
Erhard Bappert, Weil am Rhein, DE;
Inventors:
David Hook, Rheinfelden, CH;
Bernhard Riss, Huningue, FR;
Jianguang Zhou, Suzhou, CN;
Yunzhong Li, Juangsu, CN;
Erhard Bappert, Weil am Rhein, DE;
Assignee:
Novartis AG, Basel, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 229/34 (2006.01); C07C 271/22 (2006.01); C07C 227/22 (2006.01); C07C 227/20 (2006.01); C07C 269/06 (2006.01); C07D 207/267 (2006.01); C07D 207/27 (2006.01); C07D 207/33 (2006.01); C07D 207/38 (2006.01); C07C 227/18 (2006.01); C07D 207/24 (2006.01); C07D 207/277 (2006.01); C07C 229/30 (2006.01); C07C 231/10 (2006.01);
U.S. Cl.
CPC ...
C07C 271/22 (2013.01); C07C 227/18 (2013.01); C07C 227/20 (2013.01); C07C 227/22 (2013.01); C07C 229/30 (2013.01); C07C 229/34 (2013.01); C07C 231/10 (2013.01); C07C 269/06 (2013.01); C07D 207/24 (2013.01); C07D 207/267 (2013.01); C07D 207/27 (2013.01); C07D 207/277 (2013.01); C07D 207/33 (2013.01); C07D 207/38 (2013.01); C07B 2200/07 (2013.01);
Abstract
The invention relates to a new process for producing useful intermediates for the manufacture of NEP inhibitors or prodrugs thereof, in particular NEP inhibitors comprising a γ-amino-δ-biphenyl-α-methylalkanoic acid, or acid ester, backbone, such as N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.