The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 31, 2017

Filed:

Apr. 22, 2013
Applicant:

Vanderbilt University, Nashville, TN (US);

Inventors:

Scott A. Guelcher, Thompson Station, TN (US);

Jerald Dumas, Nashville, TN (US);

Edna M. Prieto, Nashville, TN (US);

Anne Talley, Nashville, TN (US);

Andrew Harmata, Nashville, TN (US);

Katarzyna Zienkiewicz, Nashville, TN (US);

Assignee:

Vanderbilt University, Nashville, TN (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 47/46 (2006.01); A61K 47/02 (2006.01); A61K 38/18 (2006.01);
U.S. Cl.
CPC ...
A61K 47/46 (2013.01); A61K 38/18 (2013.01); A61K 38/1875 (2013.01); A61K 47/02 (2013.01);
Abstract

Embodiments of the present inventions comprise composites of polyurethane(s), osteoconductive matrix, and, optionally, a growth factor. Embodiments further comprise methods of making such composite and uses thereof. The osteoconductive matrix can be a tricalcium phosphate, bioglass, or the like, and can include particles that are surface modified. Growth factors can be provided in powder form, including bone morphogenic proteins such as rhBMP-2. A composition may be moldable and/or injectable. After implantation or injection, a composition may be set to form a porous composite that provides mechanical strength and supports the in-growth of cells.


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