The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2017
Filed:
Jul. 21, 2016
Applicant:
The University of Tokyo, Tokyo, JP;
Inventors:
Kenya Honda, Tokyo, JP;
Koji Atarashi, Tokyo, JP;
Kikuji Itoh, Tokyo, JP;
Takeshi Tanoue, Tokyo, JP;
Assignee:
The University of Tokyo, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/74 (2015.01); A61K 39/08 (2006.01); A61K 45/06 (2006.01); G01N 33/50 (2006.01); A61K 45/00 (2006.01); A01K 67/027 (2006.01); C12Q 1/68 (2006.01); A61K 9/00 (2006.01); A61K 35/742 (2015.01); A61K 35/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/08 (2013.01); A01K 67/0275 (2013.01); A61K 9/0053 (2013.01); A61K 35/74 (2013.01); A61K 35/742 (2013.01); A61K 45/00 (2013.01); A61K 45/06 (2013.01); C12Q 1/689 (2013.01); G01N 33/505 (2013.01); A01K 2267/0325 (2013.01); A61K 35/00 (2013.01); A61K 2039/52 (2013.01); G01N 2333/33 (2013.01); G01N 2500/10 (2013.01);
Abstract
It was found that bacteria belonging to the genusinduce accumulation of regulatory T cells (Treg cells) in the colon. Moreover, the present inventors found that regulatory T cells (Treg cells) induced by from these bacteria suppressed proliferation of effector T-cells. From these findings, the present inventors found that the use of bacteria belonging to the genusor a physiologically active substance derived therefrom made it possible to induce proliferation or accumulation of regulatory T cells (Treg cells), and further to suppress immune functions.