The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 31, 2017
Filed:
Mar. 01, 2013
Applicant:
The Regents of the University of California, Oakland, CA (US);
Inventors:
Qizhi Tang, San Francisco, CA (US);
Jeffrey A. Bluestone, San Francisco, CA (US);
Assignee:
The Regents of the University of California, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 5/00 (2006.01); C12N 5/02 (2006.01); A61K 35/17 (2015.01); A61K 31/436 (2006.01); A61K 31/5377 (2006.01); A61K 31/573 (2006.01); C12N 5/0783 (2010.01); A61K 39/00 (2006.01); C12N 5/0781 (2010.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 31/436 (2013.01); A61K 31/5377 (2013.01); A61K 31/573 (2013.01); A61K 39/001 (2013.01); C12N 5/0635 (2013.01); C12N 5/0637 (2013.01); C12N 2501/04 (2013.01); C12N 2501/2304 (2013.01); C12N 2501/515 (2013.01); C12N 2502/1107 (2013.01); C12N 2502/30 (2013.01);
Abstract
The present disclosure relates generally to the manufacture of regulatory T cells (Tregs) for use in immunotherapy. In particular, the present disclosure relates to robust approaches for the expansion of alloantigen-reactive Tregs ex vivo. Alloantigen-reactive Tregs produced in this way are suitable for the induction and/or maintenance of immunologic tolerance in recipients of allogeneic transplants.