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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 9801901 B1

PDFFull Text
Date of Patent:
Oct. 31, 2017

Filed:

Apr. 27, 2015

Alginate oligomers for use in overcoming multidrug resistance in bacteria

Applicant:

Algipharma As, Sandvika, NO;

Inventors:

Edvar Onsoyen, Sandvika, NO;

Rolf Myrvold, Sandvika, NO;

Arne Dessen, Sandvika, NO;

David Thomas, Cardiff, GB;

Timothy Rutland Walsh, Cardiff, GB;

Assignee:

ALGIPHARMA AS, Sandvika, NO;

Attorney:

Knobbe, Martens Olson & Bear, LLP

Primary Examiner:

Dirk Bass

Int. Cl.
CPC ...
A01N 37/18 (2006.01); A61K 38/04 (2006.01); A61K 31/734 (2006.01); A61K 31/7048 (2006.01); A61K 31/7052 (2006.01); A61K 45/06 (2006.01); A01N 43/22 (2006.01); A01N 43/60 (2006.01); A01N 43/72 (2006.01); A01N 43/78 (2006.01); A01N 43/86 (2006.01); A01N 43/90 (2006.01); A61K 31/407 (2006.01); A61K 31/427 (2006.01); A61K 31/496 (2006.01); A61K 31/546 (2006.01); A61K 31/65 (2006.01); A61K 31/7028 (2006.01);
U.S. Cl.
CPC ...
A61K 31/734 (2013.01); A01N 37/18 (2013.01); A01N 43/22 (2013.01); A01N 43/60 (2013.01); A01N 43/72 (2013.01); A01N 43/78 (2013.01); A01N 43/86 (2013.01); A01N 43/90 (2013.01); A61K 31/407 (2013.01); A61K 31/427 (2013.01); A61K 31/496 (2013.01); A61K 31/546 (2013.01); A61K 31/65 (2013.01); A61K 31/7028 (2013.01); A61K 31/7048 (2013.01); A61K 31/7052 (2013.01); A61K 45/06 (2013.01);
Abstract

The invention provides a method of overcoming resistance to at least one antibiotic in a multidrug resistant bacterium, said method comprising contacting said bacterium with an alginate oligomer together with the antibiotic. The multidrug resistant bacterium may be on an animate or inanimate surface and both medical and non-medical uses and methods are provided. In one aspect the invention provides an alginate oligomer for use together with at least one antibiotic in treating a subject infected, suspected to be infected, or at risk of infection, with a multidrug resistant bacterium to overcome resistance to the antibiotic in said multidrug resistant bacterium. In another aspect the method can be used to combat contamination of a site with multidrug resistant bacteria, e.g. for disinfection and cleaning purposes.

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