The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 31, 2017

Filed:

Aug. 28, 2014
Applicant:

Georg-august-universitaet Goettingen Stiftung Oeffentlichen Rechts, Universitaesmedizin, Goettingen, DE;

Inventors:

Wolfram Hubertus Zimmermann, Goettingen, DE;

PohLoong Soong, Goettingen, DE;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 9/00 (2006.01); A61F 2/24 (2006.01); C12N 5/071 (2010.01); A61K 35/28 (2015.01); A61K 35/33 (2015.01); A61K 35/34 (2015.01); A61K 35/44 (2015.01); A61K 45/06 (2006.01); A61L 31/00 (2006.01); A61L 31/16 (2006.01);
U.S. Cl.
CPC ...
A61K 9/009 (2013.01); A61F 2/2481 (2013.01); A61K 35/28 (2013.01); A61K 35/33 (2013.01); A61K 35/34 (2013.01); A61K 35/44 (2013.01); A61K 45/06 (2013.01); A61L 31/005 (2013.01); A61L 31/16 (2013.01); C12N 5/0697 (2013.01); A61L 2300/414 (2013.01); A61L 2430/20 (2013.01);
Abstract

A pouch-like structure useful for mechanically preventing distension and/or resisting dilation of the heart and for supporting the hearts function by controllable and paracrine support of a failing heart in a mammal, is composed at least partly of engineered tissue with genetically engineered cells other than cardiac myocytes. The genetically engineered cells contain a gene encoding a paracrine factor which is under control of an inducible promoter system or a heterologous promoter system. The preparation of the pouch-like structure may be used for therapeutic, disease modelling, and drug development applications.


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