The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2017
Filed:
Jul. 22, 2014
Applicant:
The Scripps Research Institute, La Jolla, CA (US);
Inventors:
Alexander Deiters, La Jolla, CA (US);
T. Ashton Cropp, Richmond, VA (US);
Jason W. Chin, Cambridge, GB;
J. Christopher Anderson, San Francisco, CA (US);
Peter G. Schultz, La Jolla, CA (US);
Assignee:
The Scripps Research Institute, La Jolla, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); G01N 33/58 (2006.01); C07C 227/22 (2006.01); C07C 229/36 (2006.01); C07C 269/06 (2006.01); C07C 311/41 (2006.01); C07K 1/107 (2006.01); C07K 1/13 (2006.01); C07K 14/00 (2006.01); C09B 11/08 (2006.01); C09B 57/00 (2006.01); C12N 9/00 (2006.01); C12N 15/67 (2006.01); C12P 17/04 (2006.01); C12P 21/02 (2006.01); G01N 33/532 (2006.01); C07K 16/18 (2006.01);
U.S. Cl.
CPC ...
G01N 33/583 (2013.01); C07C 227/22 (2013.01); C07C 229/36 (2013.01); C07C 269/06 (2013.01); C07C 311/41 (2013.01); C07K 1/1072 (2013.01); C07K 1/13 (2013.01); C07K 14/001 (2013.01); C07K 16/18 (2013.01); C09B 11/08 (2013.01); C09B 57/00 (2013.01); C12N 9/93 (2013.01); C12N 15/67 (2013.01); C12P 17/04 (2013.01); C12P 21/02 (2013.01); G01N 33/532 (2013.01); G01N 33/582 (2013.01); C12N 2510/02 (2013.01);
Abstract
This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in eukaryotic cells. The components include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNAs/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in eukaryotic cells are also provided.