The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2017
Filed:
Jul. 09, 2014
Applicant:
The Translational Genomics Research Institute, Phoenix, AZ (US);
Inventors:
Nhan Tran, Phoenix, AZ (US);
Nathalie Meurice, Scottsdale, AZ (US);
Harshil Dhruv, Phoenix, AZ (US);
Hongwei Yin, Phoenix, AZ (US);
Assignee:
The Translational Genomics Research Institute, Phoenix, AZ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); A61K 31/167 (2006.01); A61K 31/53 (2006.01); A61K 31/47 (2006.01); A61K 31/635 (2006.01); A61K 31/542 (2006.01); A61K 31/433 (2006.01); A61K 31/498 (2006.01); A61K 31/437 (2006.01); A61K 31/4045 (2006.01); A61K 31/4155 (2006.01); A61K 31/5513 (2006.01); A61K 31/426 (2006.01); A61K 31/55 (2006.01); A61K 31/519 (2006.01); A61K 31/422 (2006.01); A61K 31/4192 (2006.01); A61K 31/541 (2006.01); A61K 45/06 (2006.01); A61K 31/4188 (2006.01); A61K 31/4704 (2006.01); A61K 31/4745 (2006.01); A61K 33/24 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5011 (2013.01); A61K 31/167 (2013.01); A61K 31/4045 (2013.01); A61K 31/4155 (2013.01); A61K 31/4188 (2013.01); A61K 31/4192 (2013.01); A61K 31/422 (2013.01); A61K 31/426 (2013.01); A61K 31/433 (2013.01); A61K 31/437 (2013.01); A61K 31/47 (2013.01); A61K 31/4704 (2013.01); A61K 31/4745 (2013.01); A61K 31/498 (2013.01); A61K 31/519 (2013.01); A61K 31/53 (2013.01); A61K 31/541 (2013.01); A61K 31/542 (2013.01); A61K 31/55 (2013.01); A61K 31/5513 (2013.01); A61K 31/635 (2013.01); A61K 33/24 (2013.01); A61K 45/06 (2013.01); G01N 33/502 (2013.01); G01N 33/5029 (2013.01); G01N 2333/525 (2013.01); G01N 2333/70575 (2013.01); G01N 2333/90241 (2013.01); G01N 2500/02 (2013.01); G01N 2500/10 (2013.01);
Abstract
The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.