The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 24, 2017

Filed:

Jul. 01, 2016
Applicant:

Acerta Pharma B.v., Oss, NL;

Inventors:

Fritz Blatter, Reinach, CH;

Tim Ingallinera, San Francisco, CA (US);

Tjeerd Barf, Ravenstein, NL;

Edwin Aret, Almere, NL;

Cecile Krejsa, Seattle, WA (US);

Jerry Evarts, Bellevue, WA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4985 (2006.01); C07D 487/04 (2006.01); A61K 45/06 (2006.01); A61K 47/36 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/4985 (2013.01); A61K 45/06 (2013.01); A61K 47/36 (2013.01); C07B 2200/13 (2013.01);
Abstract

In some embodiments, the invention relates to crystalline solid forms, including hydrates, polymorphs, and salt forms, of (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide. In some embodiments, the invention relates to amorphous solid forms of (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide. In some embodiments, the invention also relates to pharmaceutical compositions containing the solid forms, and methods for treating conditions or disorders by administering to a subject a pharmaceutical composition that includes the forms, including pharmaceutical compositions and methods for overcoming the effects of acid reducing agents.


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