The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2017
Filed:
Feb. 19, 2014
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Michael Ohlmeyer, Plainsboro, NJ (US);
David Kastrinsky, Fair Lawn, NJ (US);
Assignee:
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, New York, NY (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4353 (2006.01); C07D 487/04 (2006.01); A61K 31/517 (2006.01); C07D 333/80 (2006.01); C07D 471/04 (2006.01); A61K 31/5377 (2006.01); A61K 31/55 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); A61K 31/517 (2013.01); A61K 31/5377 (2013.01); A61K 31/55 (2013.01); C07D 333/80 (2013.01); C07D 471/04 (2013.01);
Abstract
Tricyclic chemical modulators of FOXO transcription factor proteins are disclosed. The compounds are useful to treat cancer, age-onset proteotoxicity, stress-induced depression, inflammation, and acne. The compounds are of the following and similar genera: in which Het is an aromatic heterocyclic ring and Y is a point of attachment of various side chains and rings. An example of such a compound is 4-chloro-N-(3-(10,11-dihydro-5H-benzo[b]pyrido[2,3-f]azepin-5-yl)propyl)benzenesulfonamide: