The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 24, 2017
Filed:
Dec. 22, 2014
Applicant:
Alectos Therapeutics Inc., Burnaby, CA;
Inventors:
Ramesh Kaul, Burnaby, CA;
Ernest J. McEachern, Burnaby, CA;
Jianyu Sun, Burnaby, CA;
David J. Vocadlo, Burnaby, CA;
Yuanxi Zhou, Burnaby, CA;
Yongbao Zhu, Burnaby, CA;
Assignee:
Alectos Therapeutics Inc., Burnaby, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 221/20 (2006.01);
U.S. Cl.
CPC ...
C07D 221/20 (2013.01);
Abstract
The invention provides isofogamine analogs of structural formula (I) below that modulate and stabilize glucocerebrosidases and enhance their enzymatic activity in vivo. Such compounds, prodrugs and compositions thereof are useful in treating synucleinopathy, lysosomal storage disease and relevant neurodegenerative disease.